Qiliqiangxin Affects L Type Current in the Normal and Hypertrophied Rat Heart
نویسندگان
چکیده
منابع مشابه
Qiliqiangxin Affects L Type Ca2+ Current in the Normal and Hypertrophied Rat Heart
Qiliqiangxin capsule is newly developed Chinese patent drug and proved to be effective and safe for the treatment of patients with chronic heart failure. We compared the effects of different dose Qiliqiangxin on L type Ca(2+) current (I(Ca-L)) between normal and hypertrophied myocytes. A total of 40 healthy Sprague-Dawley rats were used in the study. The rats were randomly divided into two grou...
متن کاملCalcium current in single cells isolated from normal and hypertrophied rat heart. Effects of beta-adrenergic stimulation.
The L-type calcium current was investigated in normal and hypertrophied rat ventricular myocytes as a possible cause of the action potential lengthening that has been reported during hypertrophy. Regulation of the calcium current (ICa) by a beta-adrenergic agonist (isoproterenol) was also analyzed since beta-agonist-induced positive inotropy is less marked in hypertrophied heart. Left ventricul...
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The L-type calcium current was investigated in normal and hypertrophied rat ventricular myocytes as a possible cause of the action potential lengthening that has been reported during hypertrophy. Regulation of the calcium current (lCa) by a ,B-adrenergic agonist (isoproterenol) was also analyzed since P-agonist-induced positive inotropy is less marked in hypertrophied heart. Left ventricular hy...
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15 صفحه اولImpaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure.
Infarct-induced heart failure is usually associated with cardiac hypertrophy and decreased -adrenergic responsiveness. However, conflicting results have been reported concerning the density of L-type calcium current (I Ca(L)), and the mechanisms underlying the decreased -adrenergic inotropic response. We determined I Ca(L) density, cytoplasmic calcium ([Ca2+]i) transients, and the effects of ...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2012
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2012/131830